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graph from Think Progress
This free paper has 17 double-spaced pages of easy reading text.Corruption of Pharmaceutical Markets: Addressing the Misalignment of Financial Incentives and Public Health by Marc-Andre Gagnon in the Journal of Law, Medicine and Ethics, Forthcoming at the Social Science Research Network
This paper explains how the current architecture of the pharmaceutical markets has created a misalignment of financial incentives and public health that is a central cause of harmful practices. It explores three possible solutions to address that misalignment: taxes, increased financial penalties, and drug pricing based on value. Each proposal could help to partly realign financial incentives and public health. However, because of the limits of each proposal, there is no easy solution to fixing the problem of financial incentives.
Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.
free online article at The Journal of Neuroscience “Breakthrough” dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time.
Antipsychotics often lose efficacy in patients despite chronic continuous treatment. Why this occurs is not known. It is known, however, that withdrawal from chronic antipsychotic treatment induces behavioral dopaminergic supersensitivity in animals. How this emerging supersensitivity might interact with ongoing treatment has never been assessed. Therefore, we asked whether dopamine supersensitivity could overcome the behavioral and neurochemical effects of antipsychotics while they are still in use. Using two models of antipsychotic-like effects in rats, we show that during ongoing treatment with clinically relevant doses, haloperidol and olanzapine progressively lose their efficacy in suppressing amphetamine-induced locomotion and conditioned avoidance responding.
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In recent years, excessive heat has caused more deaths than all other weather events, including floods. A heat wave is a prolonged period of excessive heat, generally 10 degrees or more above average, often combined with excessive humidity.
During a Heat Wave:
Never leave children or pets alone in enclosed vehicles.
Stay hydrated by drinking plenty of fluids, even if you do not feel thirsty. Avoid drinks with caffeine or alcohol.
Avoid extreme temperature changes.
Wear loose-fitting, lightweight, light-colored clothing. Avoid dark colors because they absorb the sun’s rays.
Slow down, stay indoors and avoid strenuous exercise during the hottest part of the day.
Postpone outdoor games and activities.
Use a buddy system when working in excessive heat. Take frequent breaks if you must work outdoors.
Check on family, friends and neighbors who do not have air conditioning, who spend much of their time alone or who are more likely to be affected by the heat.
Check on your animals frequently to ensure that they are not suffering from the heat.
Book Review – Shadow Mothers: Nannies, Au Pairs, and the Micropolitics of Mothering by Susan Sapiro at Care Work Live
One of the inspirations for Macdonald’s book comes from a personal caregiving experience. When she was 16, she was a summer babysitter/mother’s helper for a family. She had worked with the family for some time and had grown close to their children, especially the baby. One day, something happened that upset the baby and she reached for Macdonald for comfort, not her mother. Almost immediately, Macdonald was “frozen out” by the mother. Shortly after, the family paid her for the summer but let her go from the job. It wasn’t until many years later, as she started the research that became Shadow Mothers, that she understood the mother’s reaction and the complex emotions and relationships between mothers and their children’s caregivers.
Yesterday, having drunk too much, I was intoxicated as to pass all bounds; but none of the rude and coarse language I used was uttered in a conscious state. The next morning, after hearing others speak on the subject, I realised what had happened, whereupon I was overwhelmed with confusion and ready to sink into the earth with shame.
“If you use all the physics that we know now and you do what you think is a straightforward calculation, it is bad news… It may be that the universe we live in is inherently unstable and at some point billions of years from now it’s all going to get wiped out,” Lykken stated.
Studies on the Higgs’ related particles are underway and, if confirmed, the discovery can help solve the puzzle about the origin of the universe and how it will end.
“This calculation tells you that many tens of billions of years from now, there’ll be a catastrophe,” said Lykken, who is also on the science team at Europe’s Large Hadron Collider (LHC), the world’s largest and highest-energy particle accelerator.
“A little bubble of what you might think of as an ‘alternative’ universe will appear somewhere and then it will expand out and destroy us.”
commentary: make tehran a serious offer by yousaf butt
There is no evidence to indicate that Iran is currently developing nuclear weapons — in fact, the U.S. director of national intelligence, James Clapper, has a “high level of confidence” that they have made no such decision. Yet there is no reason not to strike a deal with Iran on suspending their 20 percent uranium enrichment, especially since they are amenable to such a bargain. The future trajectory of Iranian politics is uncertain, with new presidential elections due to take place in June. Given that presidential candidates are officially vetted by the Guardian Council, it is possible that the next president may be even more hardline than Mahmoud Ahmadinejad. Indeed, in most countries where the middle class is suffering under foreign-imposed hardships, the tendency is to elect more nationalistic and hawkish leaders. Witness Germany in the 1930s, for instance. And when Russia and Argentina went through a similar economic meltdown about a decade ago — as Iran is going through now — their people voted in more nationalistic leaders: Vladimir Putin and Néstor Kirchner.
Even though the Supreme Leader holds the real power in major nuclear decisions and has indicated he is firmly against nuclear weapons, it still makes sense to try to curb Iran’s enrichment work. And sanctions relief would be a small price to pay to get this concession from them.